Michelle Tylicki contributed to local, national and international campaigns focusing on radical system change. Her work promotes climate justice, animal rights, food sovereignty, racial justice, disability rights, sex work decrim, and ending blasphemy laws.

She often takes part in direct action on the frontlines of these movements and skill-shares creative tools of resistance.In her art, Tylicki creates subversive graphic design critiquing advertising (subvertising), illustration and short films. She explores physical theatre, producing and directing a climate-clown wrestling troupe, and installations like the antifascist catapult and the fridge full of 'humanely slaughtered human meat'.